Social stress in mice induces voiding dysfunction and bladder wall remodeling
نویسندگان
چکیده
منابع مشابه
Social stress in mice induces voiding dysfunction and bladder wall remodeling.
Several studies have anecdotally reported the occurrence of altered urinary voiding patterns in rodents exposed to social stress. A recent study characterized the urodynamic and central changes in a rat model of social defeat. Here, we describe a similar voiding phenotype induced in mice by social stress and in addition we describe potential molecular mechanisms underlying the resulting bladder...
متن کاملUrsolic acid induces myoglobin expression and skeletal muscle remodeling in mice
Introduction: Ursolic Acid (UA) is a lipophilic triterpenoid compound, found in large amounts in apple peel. Anabolic effects of UA on the skeletal muscle and the role of this tissue as a key regulator of systematic aging aroused this question in mind whether UA might amend skeletal muscle performances such as myoglobin expression and also whether it switches skeletal muscle fibers from glyc...
متن کاملSocial stress induces changes in urinary bladder function, bladder NGF content, and generalized bladder inflammation in mice.
Social stress may play a role in urinary bladder dysfunction in humans, but the underlying mechanisms are unknown. In the present study, we explored changes in bladder function caused by social stress using mouse models of stress and increasing stress. In the stress paradigm, individual submissive FVB mice were exposed to C57BL/6 aggressor mice directly/indirectly for 1 h/day for 2 or 4 wk. Inc...
متن کاملNormal voiding pattern and bladder dysfunction in infants and children
The normal voiding pattern and bladder dysfunction including neurogenic and non-neurogenic bladder, nocturnal enuresis and the relation between constipation and the bladder dysfunction has been reviewed in this paper. The dynamic property of lower urinary tract is complex as mature bladder function takes place in growth of the child. Recent studies have shown that cortical centre is responsible...
متن کاملSocial stress-induced bladder dysfunction: potential role of corticotropin-releasing factor Abbreviated Title: Social Stress-induced bladder dysfunction
Psychological stress can impact on visceral function with pathological consequences, although the mechanisms underlying this are poorly understood. Here we demonstrate that social stress produces marked changes in bladder structure and function. Male rats were subjected to repeated (7 days) social defeat stress using the resident-intruder model. Measurement of the voiding pattern indicated that...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2009
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.90749.2008